Burlingham 1. Jankowska-Gan 1 University of Wisconsin-Madison: Sollinger 1 University of Wisconsin-Madison: Pirsch 1 University of Wisconsin-Madison: Haynes 1 University of Wisconsin-Madison: Munoz del Rio 1 University of Wisconsin-Madison: Munoz Burlinghham Rio.
Burlingham 1 University of Wisconsin-Madison: Author information Copyright and License information Disclaimer. Corresponding Author: William J. Copyright notice.
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The publisher's final edited version of this article is available at 19 yr Burlingham for first time. See other articles in PMC that cite the published article. Abstract Background We hypothesized that T regulatory cells T R specific for donor alloantigens would protect a renal transplant during partial withdrawal of immunosuppression IS. Conclusions DSR prior to steroid withdrawal may identify a subset of transplant patients who could benefit from IS reduction without elevated risk of rejection, or deteriorating renal function.
Introduction Although the increased number and variety of immunosuppressive IS drugs have dramatically improved the short term success of organ transplantation over the past 20 years, two critical problems remain. Trial Design and Power considerations The original trial design was to enroll 75 19 yr Burlingham for first time, age 55 and older. Source of antigen Donor antigen was prepared from either fresh PBMC or frozen splenocytes as described Tall Crafers male seeking 10 Results Table 1 shows the demographics of the 32 primary kidney transplant recipients enrolled in this trial.
Table 1 Demographics of patients in DTH study. Triple Dual d DWF e 3 2 0.
Open in fro separate window. Figure 1. Rejection Prednisone at 24 mo. Figure 2. Figure 3. Serum creatinine values over a 4-year period A: Sexy married women in Choccolocco Alabama In the present study we tested the hypothesis that the presence of circulating donor antigen-specific T regulatory cells, as indicated by bystander suppression of TV-DTH, predicts safety of steroid withdrawal in older renal transplant recipients.
Footnotes Clinical Trial Registry: References 19 yr Burlingham for first time. The natural history of chronic allograft nephropathy. N Engl J Med. Organ transplantation--how much of the promise has been realized?
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Nat Med. Minimization of immunosuppression in kidney transplantation. Curr Opin Nephrol Hypertens. Mycophenolate mofetil monotherapy: Transplant Proc. Incidence and long-term cost of steroid-related side effects after renal transplantation. Am J Kidney Dis. A randomized, multicenter tlme of steroid avoidance, early steroid withdrawal or standard steroid therapy in kidney transplant recipients.
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